Possible experiment(s) dealing with the prevention of Antibiotic Resistance?

I was wondering if anyone would be able to help me in deciding a method of performing an experiment related to the prevention of Antibiotic Resistance.





(Antibiotic Resistance - the ability for micro-organisms to withstand the effects of an antibiotic - involves evolution to adapt to antibiotics).





Any help on the subject of prevention would be appreciated, but an experimental design recommendation would be ideal. I would like to perform an experiment that involves e. coli bacteria (it would be easy to acquire) and ampicillin discs (or any other practical antibiotic).





Thank you in advance for your tolerance of my large question and for answering (if you do).

Possible experiment(s) dealing with the prevention of Antibiotic Resistance?
i think that E. coli is already susceptible to ampicillin!


besides, i don't remember a way to prevent antibiotic resistence except for B-lactamase inhibitors added to B-lactam antibiotics to prevent their breakdown (resistence).


basically speaking; antibiotics inhibits a certain reaction in the bacteria that leads to its death or arrested growth (baceriocidal %26amp; static). the bacteria develop resistence by 'bypassing' this step in the reaction %26amp; develop a new pathway that forms the target product of the reaction (leaving completely the antibiotic with its action). so in these situations; the only way is to develop 'another' antibiotic (new one) that target the new pathway.


u can only prevent resistence if it is related to the given antibiotic (as i said; e.g. B-lactamase enzyme developed by bacteria that specifically attacks ur drug).]


so, u first have to thoroughly understand the cause of resistence %26amp; the pathway %26amp; work on preventing the resistence (whenever possible)


good luck :)